A behavioural pattern analysis of hypoglutamatergic mice--effects of four different antipsychotic agents.

J Neural Transm. 2001;108(10):1181-96.

A behavioural pattern analysis of hypoglutamatergic mice--effects of four different antipsychotic agents.

Nilsson M, Waters S, Waters N, Carlsson A, Carlsson ML.

Department of Pharmacology, Institute of Physiology and Pharmacology, Göteborg University, Sweden. marie.nilsson@pharm.gu.se

In a hypoglutamatergic rodent model, we have observed certain behaviours that might have relevance for the cognitive impairments seen in autism and schizophrenia.

Thus, hypoglutamatergic mice show defective habituation, impaired attention, a meagre behavioural repertoire and a general behavioural primitivization.

The aim of the present study was to characterise and quantify changes in movement pattern in mice rendered hypoglutamatergic by means of MK-801 treatment, using an automated video tracking system.

Further, the effects of four different antipsychotic drugs, the classical neuroleptic haloperidol, the atypical antipsychotic clozapine, the DA D2/5-HT2A antagonist risperidone and the selective 5-HT2A-receptor antagonist M100907, were compared with respect to effects on NMDA antagonist-induced movement pattern alterations.

We found that each receptor antagonist had a unique effect on the MK-801-induced behavioural primitivization.

Haloperidol was unable to affect the monotonous behaviour induced by MK-801, while risperidone, clozapine and M100907 produced movement patterns of high intricacy.